I just got back from my trip to West Virgina, and one of the first places my buddy Chris took me was to The Vault. Apparently, it's a pretty new place in town, and a little hard to find, as it is on a side street and there is no sign or anything else announcing that there was a bar there...
Inside is rather nice, lots of room. Good art on the walls too. The place gets its name from the room in back that has a huge ass bank vault door between the main room and the "VIP" room. The back room is pretty cool, and has some hanging chairs, which are always fun when you're drunk. When I was there, there was a good mix of people and it was a pretty good time. Also, drinks are apparently cheaper here than most places in San Francisco, so that's always nice :)